(rac)-Exatecan Intermediate 1

Cat. No.: HY-42487A Purity: 99.84%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

(rac)-Exatecan Intermediate 1 is an isomer of Exatecan Intermediate 1 (HY-42487). Exatecan Intermediate 1 (compound 6) is an intermediate of Exatecan (HY-13631), a camptothecin-based anticancer agent. Exatecan inhibits tumor growth by interfering with the proliferation and division of tumor cells by interacting with DNA. Exatecan is primarily used in research into a variety of cancers including ovarian, lung and breast cancer.

For research use only. We do not sell to patients.

(rac)-Exatecan Intermediate 1 Chemical Structure

CAS No. : 102978-40-5

Size	Price	Stock
25 mg	USD 88	Ask For Quote & Lead Time
50 mg	USD 140	Ask For Quote & Lead Time
100 mg	USD 225	Ask For Quote & Lead Time
250 mg	USD 375	Ask For Quote & Lead Time
1 g	USD 800	Ask For Quote & Lead Time

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This product is a controlled substance and not for sale in your territory.

Other Forms of (rac)-Exatecan Intermediate 1:

Exatecan Intermediate 1 Get quote
(R)-Exatecan Intermediate 1 Get quote

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Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target

Camptothecins

Molecular Weight

263.25

Formula

C₁₃H₁₃NO₅

CAS No.

102978-40-5

Appearance

Solid

Color

White to light yellow

SMILES

O=C1C(O)(CC)C(C=C23)=C(CO1)C(N3CCC2=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (379.87 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.7987 mL	18.9934 mL	37.9867 mL
5 mM	0.7597 mL	3.7987 mL	7.5973 mL
10 mM	0.3799 mL	1.8993 mL	3.7987 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (9.50 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

Purity & Documentation

Purity: 99.84%

Select Batch:

Data Sheet (277 KB) SDS (393 KB)

COA (256 KB) HNMR (182 KB) LCMS (112 KB)

Handling Instructions (2659 KB)

References

[1]. Weng W, et al. Antibody-Exatecan Conjugates with a Novel Self-immolative Moiety Overcome Resistance in Colon and Lung Cancer. Cancer Discov. 2023 Apr 3;13(4):950-973. [Content Brief]

[2]. Zhang Hongwei, et al. Intermediate for synthesizing camptothecin derivatives using exatecan mesylate and its preparation method and application. China, CN111470998. 2020-07-31.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	3.7987 mL	18.9934 mL	37.9867 mL	94.9668 mL
	5 mM	0.7597 mL	3.7987 mL	7.5973 mL	18.9934 mL
	10 mM	0.3799 mL	1.8993 mL	3.7987 mL	9.4967 mL
	15 mM	0.2532 mL	1.2662 mL	2.5324 mL	6.3311 mL
	20 mM	0.1899 mL	0.9497 mL	1.8993 mL	4.7483 mL
	25 mM	0.1519 mL	0.7597 mL	1.5195 mL	3.7987 mL
	30 mM	0.1266 mL	0.6331 mL	1.2662 mL	3.1656 mL
	40 mM	0.0950 mL	0.4748 mL	0.9497 mL	2.3742 mL
	50 mM	0.0760 mL	0.3799 mL	0.7597 mL	1.8993 mL
	60 mM	0.0633 mL	0.3166 mL	0.6331 mL	1.5828 mL
	80 mM	0.0475 mL	0.2374 mL	0.4748 mL	1.1871 mL
	100 mM	0.0380 mL	0.1899 mL	0.3799 mL	0.9497 mL